Several kinds of saprophytic fungi were tested whether acts as either pathogenic or nonpathogenic to the normal and prednisolone treated mice.
Prednisolone was administrated with 0.07 mg per gram of body weight of each experimental mouse every the other day for five times via intraperitoneal route.
Spores of Aspergillus fumigatus (27 x 105/ml), Rhizopus chinise (12 x 105/ml), Alternaria (24 x 105/ml) and Cladosporium (34 x 104/m1) were suspended in normal saline and inoculated via intravenously or intraperitoneally with 0.1 ml of these suspensions into each mouse.
The results obtained were as follows:
1. Fungal population in organs of normal and prednisolone treated mice after inoculation via intravenously with spores of each kind of fungi were no significant differences in both groups in the liver, kidneys, spleen, lungs, and heart for one week.
2. Distribution of each kind of the fungal spores in organs of normal and prednisolone treated mice after inoculation via intraperitoneally were also no obvious differences in both groups, as similar as intravenous injected mice.3. The specific inflammatory reaction in organs of mice after inoculation via intravenously with spores of each fungus revealed more marked and longer duration in the kidneys of prednisolone treated mice than those of the normal mice.
4. The specific inflammatory reaction did not occur in the mice after inoculation via intraperitoneally with spores of fungi both prednisolone treated and normal mice.
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